Anthony Hoare writes:
You should always pity the fate of the programmer whose task is so difficult that his program will not fit into the computer together with your sophisticated debugging package.
C. A. R. Hoare, "Hints On Programming Language Design," (Stanford Artificial Intelligence Laboratory, Memo AIM-224, STAN-CS-73-403, December, 1973), p. 7. http://www.eecs.berkeley.edu/~necula/cs263/handouts/hoarehints.pdf